|
KMID : 0356619940090040366
|
|
Journal of Korean Society of Endocrinology
1994 Volume.9 No. 4 p.366 ~ p.374
|
|
|
Insulin Resistance, Body Fat Distribution, and Sex Hormones in Healthy men and Premenopausal Women
|
|
오태근
신찬수/김원배/박경수/김성연/조보연/이홍규/고창순
|
|
|
Abstract
|
|
|
It is well known that obesity central obesity is associated with insulin resistance and some studies reported that sex hormones were associated with insulin resistance. Recently, Low levels of sex-hormone binding globulin(SHBG), an indirect index
of
androgenicity, have been observed to predict the development of non-insulin dependent diabetes mellitus(NIDDM) in women and SHBG has been proposed as a marker for insulin resistance. In contrast to findings in women, decreased SHBG did not
predict
the
occurrence of NIDDM in men, so it is suggested that sex hormones may have a different role for insulin resistance between men and women. To investigate the difference of the associations among the body fat distribution, sex hormones and insulin
sensitivity index in men and women, we measured body-mass index (BMI) and waist to hip circumference ratio(WHR) and concentrations of serum SHBG, total testosterone, free testosterone, and dehydroepiandrosterone sulfate(DHEA-S) concentrations in
29
healthy adults(men:19, wonen:10) who showed normal glucose tolerance. Insulin sensitivity index(M/I) was measured by euglycemic hyperinsulinemic clamp.
There were no differences in age, BMI, fasting plasma glucose, insulin and free fatty acid levels between men and women. WHR of men is higher than that of women(0.82±0.01 vs 0.73±0.01, p=0.002). Insulin sensitivity index(M/I) is similar in men
and
women(7.80±0.71mg/kg/min/uU/ml×100 vs 9.74±0.89mg/kg/min/uU/ml×100, p=0.196).
In Pearson's correlation, M/I was significantly correlated with BMI(r=-0.69, p<0.01) and WHR(r=-0.68, p<0.01) in men and DHEA-S(r=-0.68, p<0.05) and SHBG(r=0.61, p=0.056) concentrations in women
In multiple regression analysis, M/I had the most significant association with BMI(R²=0.484, β=-0.696, p<0.001) in men and DHEA-S(R²=0.471, β=-0.686, p<0.05) concentration in women.
Conclusively, we found that sex homones were significantly associated with insulin resistance and the effects of sex hormones on insulin resistance may be different in men and women. (J Kor Soc Endocrinol 9: 366-374, 1994)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|